The synthesis and structural characterization of way-120,491; a novel potassium channel activator
1991
Abstract The synthesis of the antihypertensive potassium channel activator WAY-120,491 ( 1 ) is described. X-ray crystallographic analysis of carbamate 15a established the 3S,4R configuration of 1 . The large scale classical resolution of racemic 9 was facilitated using authentic seed crystals, whose preparation was accomplished via novel coupling of racemic azidoalcohol 17 with the putative acyltriflate 20 .
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