Determination of 1-thyroxdine sodium and 1-triiodo- thyronine sodium in tablets by differential pulse polarography

Abstract Differential pulse polarograms of thyroxine and of triiodothyronine recorded from 0.1 M sodium carbonate exhibit a well-defined peak at —1.060 and —1.050 V vs.Ag/AgCl, respectively, and the peak current is proportional to the concentration in the range 10 -6 —5 × 10 -5 M. A simple and rapid method is proposed for the determination of the drugs in tablets. The procedure does not involve time-consuming extractions or decomposition of organic matter, and it is suitable for control of content uniformity in pharmaceutical formulations.