GLYCOSYLATED LOW-DENSITY LIPOPROTEIN AND OXIDIZED LOW-DENSITY LIPOPROTEIN IN TYPE 2 DIABETES MELLITUS WITH LOWER EXTREMITY VASCULAR DISEASE

[Objective] To study the relationship between type 2 diabetes mellitus with lower extremity vascular disease and the serum Glycosylated Low-density lipoprotein(GLDL) or the plasma oxidized low-density lipoprotein(OXLDL),and clarify the important of prevention and treatment of vascular lesions in the anti-glycosylated,antioxidant treatment.[Methods] The levels of the serum GLDL was measured by a fructosamine method and that of the plasma OXLDL was estimated by ELISA among 178 cases with type 2 diabetes mellitus and 60 controls.[Results] ① The levels of both the serum GLDL and the plasma OXLDL in type 2 diabetes mellitus were significantly higher than those in controls(P﹤0.01).② The levels of both the serum GLDL and the plasma OXLDL in type 2 diabetes mellitus with lower extremity vascular disease significantly increased in comparison with type 2 diabetes mellitus without lower extremity vascular disease(P﹤0.01).③ Positive correlation was found between the levels of the serum GLDL and that of the plasma OXLDL(=0.712,P﹤0.01).[Conclusion] The measurements of GLDL and OXLDL are very important clinical value in treatment of type 2 diabetes mellitus with lower extremity vascular disease.