Train to Lose: Innate Immune Memory in Metaflammation

Westernized diets and lifestyle are linked to the development of metabolic syndrome, characterized by obesity, type 2 diabetes and increased cardiovascular disease risk. Systemic low-grade inflammation is a common feature of chronic metabolic disorders and is believed to promote disease progression. Therefore, modulating inflammation is a commonly explored strategy to prevent obesity-associated co-morbidities. In this review, explore how current knowledge on the recently described concept of innate immune memory could underline metaflammation in the context of metabolic syndrome. Hence, hope to bring a new perspective to address the question of innate immune activation during disease progression. This article is protected by copyright. All rights reserved.