Calcium-Sensing Receptor of Immune Cells and Diseases
2021
Calcium-sensing receptor (CaSR), which was initially found in the parathyroid gland,
is ubiquitously expressed and exerts specific functions in multiple cells, including
immune cells. CaSR is functionally expressed on neutrophils, monocytes/macrophages,
and T lymphocytes, but not B lymphocytes, and regulates cell functions, such as cytokine
secretion, chemotaxis, phenotype switching, and ligand delivery. In these immune cells,
CaSR is involved in the development of many diseases, such as sepsis, cryopyrin-associated
periodic syndromes, rheumatism, myocardial infarction, diabetes, and peripheral artery
disease. Since its discovery, it has been controversial whether CaSR is expressed
and plays a role in immune cells. This article reviews current knowledge of the role
of CaSR in immune cells.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
68
References
0
Citations
NaN
KQI