Characterization of Mannitol Polymorphic Forms in Lyophilized Protein Formulations Using a Multivariate Curve Resolution (MCR)-Based Raman Spectroscopic Method

Yong Xie,Wenjin Cao,Sampathkumar Krishnan,Hong Lin,Nina Cauchon

Characterization of Mannitol Polymorphic Forms in Lyophilized Protein Formulations Using a Multivariate Curve Resolution (MCR)-Based Raman Spectroscopic Method

2008

Yong Xie
Wenjin Cao
Sampathkumar Krishnan
Hong Lin
Nina Cauchon

Purpose To develop a novel multivariate curve resolution (MCR)-based Raman spectroscopic method to characterize and quantify five known mannitol solid-state forms in lyophilized protein formulations.

Keywords:

Raman spectroscopy
Multivariate analysis
Mannitol
Multivariate statistics
Quantitative analysis (chemistry)
Chromatography
Analytical chemistry
Chemistry
multivariate curve resolution
pharmacology toxicology
pharmaceutical technology

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