Domain-domain communication in Band 3 of human erythrocytes

Band 3, serving as an anion transporter, is the most abundant protein in the humanerythrocyte plasma membrane. It has two strucurally and functionally distinct domains.The membrane domain is responsible for the anion exchange activity, while thecytoplasmic domain of Band 3 binds with components of the cytoskeleton (such asankyrin) to stabilize the cytoskeleton network. Although the cytoplasmic domain is not