Effects of Oestrogen on Ischemia-induced Neurogenesis in the DentateGyrus of Rats
2007
To study the effects of oestrogen on ischemia?induced neurogenesis in
the hippocampal dentate gyrus, thirty-two adult male rats were randomly
divided into four groups:the control surgery group with oestrogen
administration (SE), the control surgery group with normal saline
administration (SN), the middle cerebral artery occlusion (MCAO) group
with oestrogen administration (ME) and the MCAO group with normal
saline administration (MN). The MCAO rats were occluded for 90 min by
an intraluminal filament and then recirculated. After 1, 3, 12, 24 and
28 h of MCAO, the rats of the four groups were killed to investigate
the infarct volume, apoptosis and neurogenesis. The cerebral infarct
volume in the ME group was significantly smaller than that of the MN
group (P<0.05). No significant cell loss was seen in the dentate
gyrus. Cerebral ischemia led to increased neurogenesis, which is
independent of cell death in the ipsilateral dentate gyrus (P<0.05).
BrdU-positive cells in the ipsilateral dentate gyrus of the ME group
were significantly increased when compared with those of the MN
group(P<0.05). In the SE group, BrdU-positive cells in both the
ipsilateral and contralateral dentate gyrus, were increased when
compared with those of the SN group (P<0.05). We concluded that
oestrogen plays an important role in neurogenesis, which is independent
of ischemia-induced by MCAO in the hippocampal dentate gyrus of rats.
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