A strategy to access fused triazoloquinoline and related nucleoside analogues
2013
Abstract Fused triazoloquinolines have been prepared starting from ( E )-3-(2-nitrophenyl)-1-aryl-prop-2-en-1-ones and sugar or benzyl azides in a sequential [3+2] cycloaddition reaction, followed by one pot Pd–C assisted reduction, cyclization and aromatization. The triazolyl fused quinolines with N 1 -glycosyl substituents as unnatural nucleosides have inherent potential to generate a library of compounds for bioevaluations.
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