Ассоциации отдельных параметров рабочей памяти с полиморфизмом гена аполипопротеина E у сибирских подростков: популяционное исследование

The APOE gene is one of the most famous genes associated with the development of both cardiovascular diseases and neurodegenerative diseases of the central nervous system, accompanied by impaired cognitive functions. In the course of this study, the associations of APOE gene alleles with cognitive functions violation in the adolescent population of Novosibirsk were studied. The state of cognitive functions was evaluated in 231 boys (42.1%) and 318 girls (57.9%). Their average age was 15.66 ± 0.9 years. It was revealed that the presence of the E4 allele of the APOE gene has a negative effect on the state of working memory even in adolescence.