New insights into small airway function in Type 2 Diabetes by Impulse Oscillometry

Introduction: Pulmonary functions are impaired in Type 2 Diabetes (T2DM) because of various factors.1 Impulse Oscillometry (IOS) and Spirometry studies comparing lung functions in healthy and diabetes are lacking. Aims and Objectives: We aimed to campare lung functions between healthy and T2DM subjects using IOS and Spirometry. Methods: 24 age and gender matched non-smoking, healthy and T2DM subjects without previous lung disease underwent IOS and spirometry as per ATS and ERS guidelines. Results: In IOS, diabetics had higher R5-R20 (0.15 ±0.10 vs 0.09 ± 0.08, p=0.01), AX (1.52±1.2 vs 0.80 ±0.63, p=0.012), Delta X5 (0.189±0.25 vs 0.05± 0.04, P=0.017) in comparison to healthy. Diabetics showed reduced %FVC (82.31± 15 vs 92.87± 7.9, p=0.009), %FEV1(80.57± 15 vs 88.31 ± 10, p=0.041), %PEFR (102.77 ± 22 vs 115.08 ± 20, p=0.034) and %FEF 25-75 (56.89 ±2.21 vs 59.72 ± 2.04, p= 0.95) as compared to healthy subjects. More data will be presented in the congress. Conclusions: Higher peripheral airway resistance on IOS and reduced lung volumes on spirometry were seen in diabetics than healthy subjects. IOS evaluated small airway functions better than spirometry. Reference: 1. Teeter, J. G. & Riese, R. J. Cross-sectional and prospective study of lung function in adults with type 2 diabetes: The atherosclerosis risk in communities (ARIC) study. Diabetes Care 31, (2008).