L1 drives HSC aging and affects prognosis of chronic myelomonocytic leukemia.

Ju, Z. et al. Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat. Med. 13, 742–747 (2007). CAS Article Google Scholar De Cecco, M. et al. Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements. Aging Cell. 12, 247–256 (2013). Article Google Scholar Murnane, J. P. & Sabatier, L. Chromosome rearrangements resulting from telomere dysfunction and their role in cancer. Bioessays 26, 1164–1174 (2004). CAS Article Google Scholar Niyongere, S. et al. Heterogeneous expression of cytokines accounts for clinical diversity and refines prognostication in CMML. Leukemia 33, 205–216 (2019). CAS Article Google Scholar Download references We thank the Dr. Jian Mao (School of Medicine, Hangzhou Normal University) for technical assistance. This work was supported by Grants 2016YFA0100602, 2017YFA0103302, 2018YFA0109300 from the National Key Research and Development Program of China; Grants 81525010, 91749203, 81871116, 81501214, 91749117, 81770155, and 81771502 from the National Natural Science Foundation of China; Grants LQ14C070002 from the Natural Science Foundation of Zhejiang Province of China; Grant 2018GZR110103002 from Innovative Team Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory and Grant 2017ZT07S347 from the Program for Guangdong Introducing Innovative and Enterpreneurial Teams. This work was supported by the Science Foundation for Distinguished Young Scholars of Guangdong Province (2019B151502008) to Hu Wang. These authors contributed equally: Ying Wang, Jin-ping Zheng Key Laboratory of Aging and Cancer Biology of Zhejiang Province, Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, 311121, China Ying Wang, Junyi Wang, Lingjie Xu, Hu Wang & Zhenyu Ju Department of Public Health and Preventive Medicine, Changzhi Medical College, Changzhi, Shanxi, 046000, P. R. China Jin-ping Zheng Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, 510632, China Ying Luo, Hu Wang & Zhenyu Ju CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China Jinyong Wang Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02903, USA John M. Sedivy Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China Zhangfa Song You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar Y.W., JP.Z., H.W., Y.L., JY.W., and LJ.X. carried out the experiments. Y.W., JP.Z., H.W., JinY W., J.M.S., ZF.S., and ZY.J. analyzed the data. Y.W., JP.Z., H.W., J.M.S., and ZY.J. wrote the paper. Correspondence to Ying Wang or Zhangfa Song or Hu Wang or Zhenyu Ju. The authors declare no competing interests. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Reprints and Permissions Wang, Y., Zheng, J., Luo, Y. et al. L1 drives HSC aging and affects prognosis of chronic myelomonocytic leukemia. Sig Transduct Target Ther 5, 205 (2020). https://doi.org/10.1038/s41392-020-00279-4 Download citation Received: 26 March 2020 Revised: 27 July 2020 Accepted: 30 July 2020 Published: 19 September 2020 DOI: https://doi.org/10.1038/s41392-020-00279-4