Predicting the extent of invasive disease by MRI to enhance the use of minimally invasive techniques in the management of early stage breast carcinoma

610 Background: With the advent of minimally invasive procedures such as radio-frequency ablation and vacuum-assisted core biopsy for managing early-stage invasive breast carcinoma, the ability to predict invasive disease by pre-procedure imaging is essential to achieving an adequate margin and for guiding adjuvant therapy. Magnetic resonance imaging (MRI) is a sensitive modality used in the detection of breast pathology and may provide the anatomic resolution necessary to predict the extent of invasive disease. Methods: A retrospective review was conducted on MRI and pathologic data from 24 (63%) of 38 patients with focal, invasive breast carcinoma enrolled in an ongoing multi-modality imaging study between 3/02 and 10/03. Patients were selected on the basis of the following criteria: 1) 1 or 2 suspicious focal lesions per breast detected on MRI, 2) 1 or 2 pathologically-proven foci of invasive carcinoma per breast, and 3) no chemotherapy between MRI and definitive surgery. Largest tumor dimension as mea...