Synthesis of Propane-2,3-diol Combinatorial Monomers.
1996
Abstract Base catalyzed reaction of heterocyclic bases with R-(+)-glycidol gives heteroarylpropane-2,3-diols which are functionalized to the 3-O-dimethoxytrityl-2-O-phosphoramidites. A dimethoxytrityl-glycidol is reacted with alkyl or aryl Grignard reagents and then phosphitylated to yield 1-O-dimethoxytrityl-2-phosphoramidites. These compounds can be used for combinatorial oligomer synthesis.
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