APTES and APES Detection and Glyco Sensing Using Etched Core Fiber Bragg Grating Sensors

It is demonstrated that the etched core fiber Bragg grating sensor has sufficient sensitivity to detect the attachment of a monolayer of a low molecular weight molecule (APES) to the surface of the fiber and can differentiate this attachment from a polymeric attachment, as in the case for APTES. Hybridization and detection of DNA was successfully performed using the glutaraldehyde attachment chemistry. Also a new attachment chemistry based on glycobiology was demonstrated. Con A was successfully selectively attached to the fiber surface using glucose ligands and the attachment was detected by measuring a sizable change of the Bragg wavelength.