a new, simply labeled antagonist radioligand for imaging brain 5-HT 1A receptors with PET

Purpose We aimed to fulfill a need for a radioligand that may be simply labeled with carbon-11 for effective positron emission tomography (PET) imaging of brain 5-HT1A receptors. Methods Racemic RWAY (2,3,4,5,6,7-hexahydro-1-[4-[1[4-(2-methoxyphenyl)piperazinyl]]-2-phenylbutyryl]-1Hazepine) has high affinity for 5-HT1A receptors. The enantiomers of RWAY and O-desmethyl-RWAY, synthesized from commercially available materials, were each labeled with carbon-11 by treating the respective O