Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk

Ben Zhang,Wei Hua Jia,Koichi Matsuda,Sun-Seog Kweon,Keitaro Matsuo,Yong-Bing Xiang,Aesun Shin,Sun Ha Jee,Dong-Hyun Kim,Qiuyin Cai,Jirong Long,Jiajun Shi,Wanqing Wen,Gong Yang,Yanfeng Zhang,Chun Li,Bingshan Li,Yan Guo,Zefang Ren,Bu-Tian Ji,Zhi Zhong Pan,Atsushi Takahashi,Min-Ho Shin,Fumihiko Matsuda,Yu-Tang Gao,Jae Hwan Oh,S.U. Kim,Yoon-Ok Ahn,Andrew T. Chan,Jenny Chang-Claude,Martha L. Slattery,Stephen B. Gruber,Fredrick R. Schumacher,Stephanie L. Stenzel,Graham Casey,Hyeong Rok Kim,Jin Young Jeong,Ji Won Park,Hong Lan Li,Satoyo Hosono,Sang-Hee Cho,Michiaki Kubo,Xiao-Ou Shu,Yi Xin Zeng,Wei Zheng

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk

2014

Wei Zheng and colleagues report the results of a large-scale genome-wide association study of colorectal cancer in East Asians. They identify six new susceptibility loci, including variants near TCF7L2 and TGFB1.

Keywords:

Gene expression profiling
Locus (genetics)
TCF7L2
Colorectal cancer
Genetics
Genetic variation
Genome-wide association study
Genotype
Biology
Case-control study
susceptibility locus

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