Factors that render the kidney susceptible to tissue hypoxia in hypoxemia

To better understand what makes the kidney susceptible to tissue hypoxia, we compared, in the rabbit kidney and hindlimb, the ability of feedback mechanisms governing oxygen consumption (Vo2) and oxygen delivery (Do2) to attenuate tissue hypoxia during hypoxemia. In the kidney (cortex and medulla) and hindlimb (biceps femoris muscle), we determined responses of whole organ blood flow and Vo2, and local perfusion and tissue Po2, to reductions in Do2 mediated by graded systemic hypoxemia. Progressive hypoxemia reduced tissue Po2 similarly in the renal cortex, renal medulla, and biceps femoris. Falls in tissue Po2 could be detected when arterial oxygen content was reduced by as little as 4–8%. Vo2 remained stable during progressive hypoxemia, only tending to fall once arterial oxygen content was reduced by 55% for the kidney or 42% for the hindlimb. Even then, the fall in renal Vo2 could be accounted for by reduced oxygen demand for sodium transport rather than limited oxygen availability. Hindlimb blood...