Nano-sized carriers for capsaicinoids with topic analgesic and anti-inflammatory effects.

Capsaicinoids confer the pungency in chili peppers and are proven to contain many beneficial traits, among them analgesic and anti-inflammatory properties. Capsaicinoids produce a burning sensation when administered and have other secondary effects given their pungency. This is why many drug delivery vehicles have been tested to prove their efficacy in reducing the secondary effects of these compounds while still having its primary beneficial effects. There are many articles that talk about the formulation of drug delivery systems and their properties yet there is little information on the therapeutic effects of applying these drug delivery systems. This review is focused on studies' results that prove efficacy of capsaicinoids specially in those that use them in nano-sized drug delivery systems. Nano-sized carriers have been proven to reduce the secondary effects of capsaicinoids while improving the bioavailability, absorption, anti-inflammatory and analgesic properties of these compounds.