A Catellani and retro-Diels-Alder strategy to access 1-amino phenanthrenes via ortho- and interannular C-H activations of 2-iodobiphenyls

An efficient palladium-catalyzed three-component domino reaction of 2-iodobiphenyls, O-benzoylhydroxylamines, and norbornadiene has been developed to construct diverse 1-amino phenanthrene derivatives. The methodology realizes simultaneous construction of one C-N bond and two C-C bonds via a Catellani and retro-Diels-Alder strategy by ortho- and interannular C-H activation of 2-iodobiphenyls. Furthermore, this methodology features good functional group and broad substrate scope.