Optical Coherence Tomography Quadrant Analysis of Retinal Nerve Fiber Layer in Relapsing and Remitting Multiple Sclerosis (P6.297)

Objective: Assess the effects of unilateral and bilateral optic neuritis (ON) on advanced optical coherence tomography (OCT) measurements in Relapsing and Remitting MS (RRMS). Background: OCT measurements include more detailed evaluations of retinal nerve fiber layer (RNFL) by sector. Methods: OCT measures of RNFL thickness and total macular volume (TMV) were studied in 238 RRMS patients and 68 controls. Results: There were 128 MS patients (54%) who did not have a history of ON (MS Unaffected) and 110 MS patients (46%) who did have prior ON (MS Affected). Mean RNFL thickness was higher in controls (98 ± 9 μm) compared to MS unaffected (91 ± 11 μm) and MS affected eyes (78 ± 13 μm) (p Disclosure: Dr. Rose has received research support from Teva Neuroscience, and Biogen Idec. Dr. Fjeldstad has nothing to disclose.