Hydrogel allergic contact dermatitis and imidazolidinyl urea/diazolidinyl urea

Hydrogels contain modified carboxymethylcellulose polymer together with propylene glycol as known components. Nowadays, they are common agents used in the treatment of leg ulcer patients, and a possible cause of allergic contact dermatitis. However in the published data, not all the patients with positive patch tests to hydrogels were sensitized to propylene glycol, remaining some allergens to be identified. The authors describe two leg ulcer patients sensitized for different commercial available hydrogels tested “as is”, with concomitant patch tested positivity to imidazolidinyl urea (IU) and diazolidinyl urea (DU). Patient A was an 84-year-old male, and patient B was a 77-year-old female, both with a known history of leg ulcer for more than 8 weeks. Patient A was sensitized for Intrasite Gel®, Hydrogel Nu-Gel®, Askina Gel®, neomycin and budesonide. Patient B was sensitized for Intrasite Gel®, Hydrogel Nu-Gel®, Askina Gel®, Hydrosorb Gel®, Fragance mix 1 and 2, Amerchol, geraniol and citral. They were ne...