[Expression of CD4(+) and IL-17, Foxp3 in non-small cell lung cancer and their correlation with microvessel density].

Objective To explore the expression of CD4^ ＋ , IL-17 and Foxp3 in non-small cell lung cancer （NSCLC） and their relationship with microvessel density （MVD）. Methods The expressions of CD4^＋, IL-17, Foxp3, CD31 and CD34 in the cancer tissues of 102 NSCLC cases were detected by immunohistochemisty. The relationship among the expressions of CD4^＋, IL-17, Foxp3 and MVD was analyzed. The count data were analyzed using X2 test. The measurement data were analyzed using singlefactor analysis of variance, and significance level α = 0.05. Results Among the factors affecting CD31 expression, there was a statistically significant difference between the strong positive Foxp3 expression （ ＋ ＋） and negative （ - ） and positive expressions （ ＋ ） in the NSCLC cancer tissues （ P 〈 0.05 ） , and between the expressions in stage [ and Ill cancer tissues （ P 〈 0.05 ）. Among the factors affecting CD34 expression, there was a significant difference between positive IL-7 expression （ ＋ ） and strong positive IL-7 expression （ ＋ ＋ ） （P 〈 0. 05 ）, between negative Foxp3 expression （ - ） and strong positive Foxp3 expression （ ＋ ＋）（P 〈0.05）, and between the CD34 expressions in stage Ⅰ and Ⅲ and between those in stage l~ and HI NSCLC cancer tissues （P 〈 0.05）. Conclusions CD4, IL-17and Foxp3 may be involved in the tumor suppression caused by host immune response, and are related with the NSCLC invasion and metastasis. Key words: Carcinoma, non small cell lung;  CD4 ;  IL-17 ;  Foxp3 ;  Tumor immunity ;  pTNM stage;  Neoplasm metastasis