Overcoming COVID-19 vaccine hesitancy in people with multiple sclerosis

Introduction: The general recommendation of health regulatory authorities worldwide is that people with MS (PwMS) should be vaccinated for Covid-19. However, no data has been documented as to how the MS population has responded to this recommendation. Objective: In this special report, we present novel information as to the compliance, beliefs and attitudes towards Covid-19 vaccines in PwMS. Methods: Following an online educational programme including updated information on the Covid-19 infection and the administration of the vaccination to PwMS, an open online survey of 14 questions was distributed. The survey was open for a 25-day period during January 2021. The participants reported if they had been or are presently infected with Covid-19. If yes, participants were asked to report the severity and length of the symptoms. If no, they were asked to report if they had received or intended to receive the Covid-19 vaccine. Additional questions focused on their decision to receive or not receive the vaccine. Only completed questionnaires were analyzed. Results: The sample included 204 PwMS;63.6% were females with a mean age of 45.5 (S.D.=14.0). Ten patients have been infected and 2 were hospitalized due to the virus. Regarding the Covid-19 vaccine, 37.1% (n=72) responded that they had already been vaccinated;122 who had as yet not been vaccinated, 70.5% (n=86) replied that they were planning to receive the vaccine. Thirty-six (29.5%) PwMS responded that they did not intend to take the vaccine. Major reasons for Covid-19 vaccination refusal were fear of disease worsening and/or MS relapse (n=14), and doubts that the vaccine was safe or beneficial (n=6). Nevertheless, 79.5% (29/36) reported that in the event of obtaining new medical information on the efficacy of the vaccine or a recommendation by their treating neurologist, they would reconsider and agree to be vaccinated. Seven (out of 36, 20.5%) responded that they were determined not to receive the Covid-19 vaccine, irrespective, of any advice. Conclusions: We suggest that medical professionals involved in MS patient care, also be involved in Covid-19 related educational programs, specifically, on the issue of vaccination. The ability to enhance patient's knowledge, behaviors, and attitudes can certainly produce a change and increase patient compliance, confidence and receptivity to receive the Covid-19 vaccine and prevent health complications caused by this destructive virus.