[Correlation between HLA-DRB1*0901 and 1501, HLA-DQB1*0301 and 0602 alleles and esophageal squamous cell carcinoma of Kazakh in Xinjiang, China].

Objective To investigate the polymorphism of HLA-DRB1 and DQB1 allele in esophageal squamous cell carcinomas of Kazakh in Xinjiang, and to characterize susceptible genes for the family of Kazakh esophageal squamous cell carcinoma Methods HLA-DRB1 * 0901, DRB1 * 1501, DQB1 * 0301, DQB1 * 0602 alleles were genotyped by sequence specific primers using polymerase chain reaction ( PCR-SSP) in 200 Kazakh esophageal squamous cell carcinoma and 177 normal esophageal mucosa. Results The frequency of HLA-DRB1 * 1501, HLA-DQB1 * 0301, HLA-DQB1 * 0602 alleles in 200 Kazakh esophageal squamous cell carcinoma (0. 455, 0. 760 and 0. 690) were significantly higher than that of 177 normal esophageal mucosa (0. 232, 0. 520, 0. 554; OR = 2. 78, 2. 93,1. 80; P 0. 05) ;The frequency of HLA-DQB1 * 0602 was higher in poor-differentiated squamous cell carcinomas (0. 742) than that of well-differentiated tumors (0. 597, P <0. 05). Conclusions HLA-DRB1 * 1501, HLA-DQB1 * 0301, HLA-DQB1 * 0602 may be susceptible to Kazakh esophageal squamous cell carcinoma. HLA-DQB1 * 0602 correlates with well-differentiated esophageal squamous cell carcinoma. Key words: Esophageal neoplasms; Carcinoma;  squamous cell; HLA antigens; Genes;  MHC class Ⅱ ; Genetic predisposition to disease; Ethnic groups