Anthraquinone Glycosides from the Roots of Prismatomeris connata

Abstract Aim To study the anthraquinone glycosides and their cytotoxicity from the roots of Prismatomeris connata . Methods The chemical constituents were isolated by Diaion HP-20 resin, silica gel, Sephadex LH-20 and ODS column chromatography and the structures were elucidated on the basis of spectral analysis. The cytotoxic activity was evaluated by MTT method. Results Six known anthraquinone glycosides were obtained and their structures were identified as 1- O -methylrubiadin 3- O -β-primeveroside ( 1 ), damnacanthol 3- O -β-primeveroside ( 2 ), rubiadin 3- O -β-primerveroside ( 3 ), lucidin 3- O -β-primeveroside ( 4 ), 1, 3-dihydroxy-2-(methoxymethyl) anthraquinone 3- O -β-primerveroside ( 5 ), and digiferruginol ω-gentiobiose ( 6 ). Conclusion All the compounds were isolated from this genus for the first time.