OB-04 : The usefulness of maternal serum C-reactive protein and lipid peroxide in the prediction of the interval between membrane rupture and delivery in preterm premature rupture of membrane

The aim of this prospective study was to evaluate the usefulness of maternal serum C-reactive protein (CRP), lipid peroxide and other variables in predicting the interval between membrane rupture and delivery in patients with preterm premature rupture of membrane (PPROM). 72 patients (gestational age <34weeks) with PPROM and delivered by spontaneous vaginal delivery were analyzed. Patients were categorized into two groups; delivery within 3 days (group A) or after 3 days (group B) since PPROM. Maternal blood samples were collected at the time of admission. The levels of CRP, lipid peroxide, and protein carbonyl have been compared between group A and B. Other possible risk factors such as WBC count, amniotic fluid index (AFI), Bishop score, and cervix length on admission were also compared. CRP concentration was measured by latex agglutination method. The levels of lipid peroxide and protein carbonyl were measured by thiobarbituric acid reaction and 2, 4-dinitrophenylhydrazine method, respectively. Maternal serum CRP and lipid peroxide levels were higher in group A compared with group B (p< 0.001, and p=0.001). Bishop score was higher in group A than group B (p< 0.001). There were no statistically significant differences in WBC, neutrophil to lymphocyte ratio, protein carbonyl levels, AFI and cervix length between group A and group B. ROC curve analysis showed that CRP (cutoff value; 0.4, area under the curve=0.673, p<0.01) and lipid peroxide (cutoff value; 2.27, area under the curve=0.741, p<0.005) level on admission are predictive of delivery within 3days after PROM. CRP and lipid peroxide levels in maternal serum, and bishop score on admission may be useful to predict the interval between membrane rupture and delivery in patients with PPROM.