Synthesis of Propargylaminesby Three-Component Coupling of Aldehydes, Amines and Alkynes Catalyzedby Magnetically Separable Copper Ferrite Nanoparticles

An efficient three-component coupling of aldehydes, amines and alkynes has been developed to prepare propargylamines in nearly quantitative yields using magnetically separable copper ferrite nanoparticles as catalyst. Structurally divergent aldehydes and amines were converted into the corresponding propargyl­amines. The reaction does not require any co-catalyst.