Abstract 18321: Serum Cardiac Myosin Binding Protein-C Correlates With Severity of Overall Cardiovascular Stress

Introduction: Cardiac Myosin Binding Protein-C (cMyBP-C) is a heart muscle thick filament protein that regulates contractility and lusitropy. Significant serum cMyBP-C levels occur independent of myocardial infarction (MI). Hypothesis: Serum cMyBP-C levels reflect patients’ overall cardiovascular disease status and can be used to predict future events. Methods: We prospectively enrolled patients who are undergoing exercise stress echocardiography, then collected blood samples at pre-test and immediately after stress. We followed patients for primary outcome (PO: sudden death, MI, revascularization, and hospitalization for any cardiac cause) and critical events (CE: death, MI, life-threatening arrhythmia, pulmonary embolism, stroke, and syncope) for 12-18 months. Results: We enrolled 75 men (age 59±14) and 83 women (age 56±11). Exercise stress increased serum cMyBP-C on all subjects. cMyBP-C increases correlated with basal levels (r=0.77, p<0.001). cMyBP-C increases did not correlate to duration, intensity...