Artesunate Effect Chemotaxis Function of Neutrophil

Objective To observe that whether artesunate can suppress chemotaxis function of neutrophil or not and to explore partly anti-inflammation activity of artesunate. Methods Both artesunate group mice and control group mice were injected LTB4 at subcutis,then we compared to quantity of polymorphonuclear cell in skin histopathology examina- tion; To compare to quantity of neutrophil with resulting from IL-8 as chemotactic reagent between artesunate group and control group in human peripheral blood;to evaluate efficacy in artesunate treatment experimental ICD. Results Quantity of polymorphonuclear cell in artesunate goup was less than that in the control group;Chemotaxis function of neutrophil in the artesunate group was lower than that in the control group;The time of fully recovery from illness was shorter in artesu- nate group than that in control group. Conclusion The study indicates that one of mechanisms of anti-inflammation of arte- sunate may be that neutrophil'chamotaxis function is suppressed by artesunate.