Pacifier biosensor: Towards non-invasive saliva biomarker monitoring

Wearable sensors for non-invasive monitoring of physiological parameters is a growing technology in the clinical field. Espe-cially in neonates, the development of portable and non-harmful monitoring devices is urgently needed because they cannot provide any feedback about discomfort or health complaints. However, in infants monitoring, only wearable sensors meas-uring physical parameters for vital signs have been developed. Here, we describe the first chemical wearable sensor for new-borns monitoring. This fully-integrated pacifier operates as a portable wireless device towards non-invasive chemical moni-toring in the infant’s saliva. The infant’s mouth movements on the pacifier result in efficient saliva pumping and promote unidirectional flow from the mouth to the electrochemical chamber. The integrated electrochemical detection chamber, con-taining the enzymatic biosensor, is located outside of the oral cavity. The capabilities of the platform were studied for glucose detection in diabetic adults and ...