Spontaneous Tumors in p53-Deficient Mice

The p53-deficient mice (Riken mice) were examined for tumors occurring spontaneously histopathologically and hematologically. Histopathologically, 87% of the males with tumors and 86% of the females with tumors had malignant lymphomas or lymphatic hyperplasia. It must be safe to say that more marked tendency to have spontaneous malignant lymphomas is seen in the p53-deficient mouse.