HypovitaminosisDCorrectionandHigh-Sensitivity C-ReactiveProteinLevelsinHypertensiveAdults

Context:�HypovitaminosisDhasbeenimplicatedasapos- sibleriskfactorforthedevelopmentofcardiovasculardisease.� High-sensitivityC-reactiveprotein�(hs-CRP)�hasbeenoneofthe� mostextensivelystudiedbiomarkersforcardiovascularinflam - mationasanindicatorofdiseaseandeventrisk,�independent� oftraditionalriskfactors.�Todate,�itisunclearifcorrectionof� hypovitaminosisDleadstoareductionofhs-CRPinhuman� subjects. Objectives:�Toassesslaboratoryvalidityof�25-hydroxyvita- minD�(25-OH-vitaminD)�andhs-CRPmeasurementsandto� determinewhetherhs-CRPlevelsinadultswithwell-controlled� hypertensionandcomorbidlowvitaminDlevelschangedafter� hypovitaminosisDcorrectiontoaserum�25-OH-vitaminDlevel� greaterthan�30�ng/mL. Design:�Prospectivestudyusinganunblindeddesign. Results:� OnehundredeightsubjectswhowerevitaminD� insufficientordeficientcompletedthisstudy.�Themean�25-OH- vitaminDlevelwas�20.07�ng/mLbeforetreatmentand�43.92� ng/mLaftertreatment.�PosttreatmentvitaminDlevelswerein� thenormalrangefor�91%�ofthesubjects.�Nostatisticallysig- nificantchangesinhs-CRPlevelweredetectedafterthevitamin� DtreatmentwasadministeredandaposttreatmentvitaminD� levelabove�30�ng/mLwasconfirmed.�