DUAL ANTIPLATELET THERAPY AND LONG-TERM CLINICAL OUTCOMES AFTER PRIMARY PCI: THE HORIZONS-AMI TRIAL

Absrac Caegor 21. harmacoherap - Ierveoal Aspecsreseao umber 2501-6Auhors Georgios J. Vlachojannis, Roxana Mehran, Bernhard Witzenbichler, Giulio Guagliumi, Jan Z. Peruga, Bruce Brodie, Martin Fahy, Ran Kornowski, Bernard Gersh, Helen Parise, George Dangas, Gregg Stone, Cardiovascular Research Foundation, New York, NY, USA, Mount Sinai Medical Center, New York, NY, USAObjective: To assess he assocao o dual aplaele herap (A) use ad log-erm clcal oucomes paes udergog prmar seg or S-segme elevao mocardal arco (SEMI).Methods: HIS-AMI was a prospecve, radomed ral o paclaxel-elug ses (ES) vs. bare meal ses (BMS) 3,006 paes udergog prmar CI or SEMI. Ladmar aalss was perormed 2,581 paes who remaed ree rom deah, mocardal arco (MI), revascularao, se hromboss (S) or major bleedg a 12-moh ollow-up, sraied accordg o A usage a hs me. Secodar aalses were perormed accordg o radomed se pe. he prmar edpos were assessed a 36-moh ollow-up ad cluded he compose oucome measure o major adverse cardovascular eves (MACE; deah, MI, schemc-drve arge-leso revascularao (L), S or sroe) ad e adverse clcal eves (ACE; major bleedg or MACE) as well as he dvdual compoes o he compose edpos.Results: A 12 mohs 1,781 eve-ree paes (69%) were sll ag A (‘o A’) ad 800 eve-ree paes (31%) had dscoued DA (‘o A’). I he pooled aalss, a 36 mohs here were o sgica dereces oucomes bewee he ‘o A’ ad ‘o DA’ groups wh regards o raes o deah, L, sroe, S ad major bleedg as well he combed edpos MACE ad ACE. However, he rae o MI a 36 mohs was sgical hgher he ‘o A’ group (2.8% o vs. 4.4% o, p=0.04). Amog paes recevg ES, he ‘o A’ group had sgical lower 1-3 ear raes o MI (2.6% o A vs. 4.8% o A, p=0.01) ad S (1.2% o A vs. 2.5% o A, p=0.04 6). Amog paes recevg BMS here were o sgica dereces oucomes bewee he ‘o A’ or ‘o A’ groups.Conclusions: Coug A usage aer 12 mohs eve-ree paes aer prmar CI or SEMI reaed wh ES ma reduce subseue raes o MI ad S, warrag deive radomed rals or hs applcao.