PROGNOSTIC FACTORS OF AUTOIMMUNE INFLAMATION FOR RHEUMATOIDARTHRITIS

The pathogenesis of rheumatoid arthritis (RA) is described, including the significance of IL-1, IL-6, IL-17, the CD40R / CD40L system, metalloproteinases, TNF-alpha. Activation of the humoral response is the basis for the development of the autoimmune process. Levels of IL-6, IL-17, CD40L and MMP-3 clearly reflect the degree of activity of the inflammatory process, and is also an important addition to the main diagnostic markers of PAT. New approaches to predicting the course of rheumatoid arthritis in children and juvenile rheumatoid arthritis in children are also described. Thus, in RA it is possible to have a wide spectrum of organ-specific and organ-specific autoantibodies, accompanied by damage to a number of organs and systems, however, the mechanism and specific aspects of the relationship between organ damage and the nature of autoantibodies need further clarification.