Effects of GGsTop® on Collagen and Glutathione in the Oral Mucosa Using a Rat Model of 5-Fluorouracil-Induced Oral Mucositis.

BACKGROUND/AIM To evaluate the usefulness of GGsTop® for oral mucositis, a quantitative study focusing on oral mucosal tissues is necessary. In this study, we aimed to quantify collagen and glutathione using a rat model of 5-fluorouracil-induced oral mucositis. MATERIALS AND METHODS Changes in ulcer area and erythrocyte count were measured to confirm the usefulness of GGsTop® for oral mucositis. The effect of GGsTop on collagen was evaluated by observing oral mucosal tissue sections and measuring the collagen concentration in the tissues. The total glutathione concentration and the oxidized glutathione concentration were measured, and the concentration of the reduced form was calculated. RESULTS GGsTop® shortened the treatment period for oral mucositis without affecting the white blood cell count. In addition, GGsTop® promoted collagen production and alleviated oxidative stress conditions. CONCLUSION GGsTop affects collagen and glutathione in the treatment of oral mucositis.