A Reusable Pb 2+ Detecting Aptasensor Employing a Gold Nanorod-DNAzyme Conjugate

Here, we demonstrated a Pb 2+ detecting aptasensor using Pb 2+ -sensitive DNAzymeconjugated gold nanorods (GNRs). Fluorescent DNA substrates that were initially quenched by GNRs, are released in response to Pb 2+ ions to give a substantial fluorescence signal. The GNR-tethered DNAzyme is reusable at least three times with a LOD of 50 nM.