Association of Matrix Metalloproteinase1-1607 1G>2G Polymorphism and Lung Cancer Risk: An Update by Meta-Analysis

Objective: The association between matrix metalloproteinase1 (MMP1)-1607 1G>2G polymorphism and lung cancerrisk is still inconclusive and inconsistent. We conducted a meta-analysis to estimate the potential relationship betweenMMP1-1607 1G>2G polymorphism and lung cancer risk. Methods: The comprehensive searches of the PubMed, Webof Science, Medline, CBM, CNKI, Weipu, and Wanfang databases, published up to Nov 10, 2018. Statistical analyseswere performed with Review Manager 5.3 software. Results: A total of 14 relevant studies containing 6068 cases and5860 controls were included in the study. The results indicated that MMP1-1607 1G>2G polymorphism was significantlyassociated with increased lung cancer risk under four models: 2G vs. 1G model (pooled OR = 1.19, 95% CI = 1.05-1.34,P 2G polymorphism was a risk factor for developing lung cancer risk.