Skeletal Muscle PPAR-delta increases with 10 Weeks of Resistance Training (LB819)

Purpose: PPARδ expression in skeletal muscle has been shown to increase in response to endurance exercise training. However, the effect of resistance exercise training on PPARδ expression has not been investigated in humans and is thus the purpose of this study. Methods: Seven untrained young men (N=5) and women (N=2) (Age=23.5±1.7, BMI=27.0±2.1) performed a 10-week progressive whole body resistance training program that included leg press and leg extension for emphasis on quadriceps femoris muscles. Muscle biopsies were performed on the vastus lateralis muscles 24 hours before the first and 24 hours after the last resistance exercise sessions to study the effect of training on PPARδ. Western Blotting was conducted to detect the PPARδ content. Results: After 10 weeks of resistance exercise training, PPARδ levels increased by 97.3% (p=0.037). Conclusion: Our data suggest that resistance exercise training has positive effects on PPARδ content, which may be a key factor of lipid metabolism.