Erkek İnfertilitesi Medikal Tedavisinde Pseudoephedrine'in Etkisi

The Effect of Pseudoephedrine In the Medical Treatment of Male Infertility Objective: To investigate the activity of a sympathomimetic drug pseudoephedrine in the medical treatment of male infertility. Materials and Method: Fifty- two sub-fertile patients whom were referred to our clinic due to infertility and with out any determined infertility pathologies in fertility assessments were retrospectively investigated. As a sympathomimetic agent 180 mg pseudoephedrine was administered to 34 patients for a period of one month. No other drugs were administered to the remaining 18 patients; these patients were the group waiting for assistive reproduction techniques. Patients were assessed according to pre- and post-therapeutic ejaculate volume, total motile sperm number and pregnancy. Results: A significant increase was determined in the ejaculate volume in the group of patients whom were treated with pseudoephedrine while no significant differences were found among patients included in both of the both groups regarding the pre- and post-therapeutic testis volumes, hormone parameters, total motile sperm number, and ratio of pregnancies (p<0,001). No any significant increases were determined in the total motile sperm number in the therapy group; however, the ratio of improvement were more significant when compared with the followed group (p<0,01). The didn’t obtain spontaneus pregnancy in neither treatment group nor control group. Conclusion : The manipulation of the sympathetic system by miscellaneous selective drugs that provide a major innervation in the males reproductive