Antimicrobial activity and structure-activity relationship of acyclic nucleosides

Various acylonucleoside analogs were synthesized and evaluated for antibacterial and antifungal activity. All the acyclic nucleosides exhibited good antifungal activity compared to the standard drug clotrimazole. However, none of the compounds possess broad-spectrum antibacterial activity. The structure-activity relationships of acyclic nucleosides were studied in order to develop the most potential antifungal agent for preclinical evaluation.