Chromatin, DNA Replication, and Transcription: Closing the Triangle

Chromatin features are correctly transferred to the daughter strands during genome replication. Recent discoveries demonstrate that replicative DNA polymerases interact physically with histone dimers and tetramers, facilitating histone transfer at the DNA replication fork. This role may explain the transcriptional phenotypic defects of Arabidopsis mutants in genes encoding DNA polymerase subunits.