The prediction roles of asymmetric dimethyl-arginine, adiponectin and apelin for macroangiopathy in patients with impaired glucose regulation

Abstract Purpose To investigate the effects of asymmetric dimethyl-arginine (ADMA), adiponectin (APN) and apelin in predicting macroangiopathy in impaired glucose regulation (IGR) patients. Methods A total of 210 patients undergoing oral glucose tolerance test were included in this study. They were classified to normal glucose tolerance (NGT, n  = 42), impaired fasting glucose (IFG, n  = 36), impaired glucose tolerance (IGT, n  = 92, including 44 IGT1 and 48 IGT2 patients) and IFG + IGT ( n  = 40) groups. APN, apelin and ADMA levels, blood pressure, blood lipid, insulin, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR) were detected. The severity and extent of coronary atherosclerosis were determined by the Gensini score. Results The prevalence of coronary heart disease and Gensini scores in IGT and IFG + IGT groups were similar but both were higher than NGT and IFG groups (all P P  P r  = 0.669) and ADMA ( r  = 0.764), but were negatively correlated with APN ( r  = –0.555, all P Conclusion ADMA and APN levels could be predictive factors for macroangiopathy in IGR patients, especially in IGT cases.