Leptin, Soluble Leptin Receptor, Lipid Profiles, and LEPR Gene Polymorphisms in Thai Children and Adolescents

Objective: To evaluate the relationships between leptin, soluble leptin receptor, lipid profiles, and LEPR gene polymorphisms in child and adolescent Thai subjects. Design: Cross-sectional study of Thai children and adolescents. Subjects: 116 male and 65 female at risk for overweight/overweight child and adolescent Thai subjects, and 33 male and 62 female healthy child and adolescent Thai subjects (age: 5–19 years). Measurements: Leptin levels, soluble leptin receptor levels, lipid profiles, LEPR gene polymorphisms. Results: Significantly higher levels of cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), and leptin levels were observed in at risk for overweight/overweight group. On the other hand, high-density lipoprotein cholesterol (HDL-C) and soluble leptin receptor levels were significantly lower in the same group. Serum soluble leptin receptor levels were significantly negatively correlated with leptin. The at risk for overweight/overweight subjects with the Lys656Lys homozygous...