Distribución de la frecuencia de síndrome coronario agudo acorde al día de la semana. Análisis del registro Epi-Cardio Weekly Distribution of Acute Coronary Syndrome. Analysis of the Epi-Cardio Registry

Background: Acute coronary syndromes (ACS) seem to have a chronobiological distribution with seasonal, weekly and circadian variations. So far, there is no evidence in the published literature about the weekly distribution of ACS in Argentina; thus, we ignore if ACS have a specific pattern and which could be the associated variables. Objective: The aim of this study was to analyze the weekly distribution of ACS and the differences in treatment and clinical outcome. Methods: The distribution of cases of non-ST-segment elevation (NSTE) ACS (n=6277) and ST-segment elevation (STE) ACS (n=4237) was retrospectively analyzed according to the day of the week using the Epi-Cardio registry 2006-2012. Results: The frequency was higher during the first days of the week and descended during the weekend (all ACS and NSTEACS p<0.001; STE-ACS p<0.01), and was not related with age or sex. In STE-ACS, the indication and the type reperfusion therapy did not present differences according the day of the week. Conclusions: The frequency of hospitalization due to ACS is higher within the first days of the workweek and decreases during the weekend, and there are no differences in the use of complex resources and in the initial outcome.