Metal modified SSA as a heterogeneous catalyst to promote the cyclocondesation of o-aminobenzonitriles with cycloketones in water

Abstract A novel solid catalyst based on silica sulfuric acid (SSA) was prepared. When SSA was treated with Lewis acids, metal ions can be easily immobilized on silica surface, which results in strengthening Lewis acidity. The novel solid catalyst was demonstrated to be efficient in promoting the cyclocondesation of o -aminobenzonitriles with cycloketones in water, and hence promising in the application of pharmaceutical study and production.