Antidiabetic and antioxidant effect of Galegaofficinalis extracts on blood biochemical and hormonal Factors Associated withDiabetes in Streptozotocin-Induced Diabetic Rats

Objective: Diabetes mellitus (DM) is impairing secretion of insulin or resistance to insulin. Herbal medicine plays an important role in the management of DM. We aimed to test anti-diabetic effects of Galega officinalis on diabetic rats. Materials and Methods: 28 male Wistar rats were randomly divided into 4 groups (n=7). Diabetes was induced by streptozotocin (50 mg/kg). Diabetic rats were calcified in to diabetic control group (DC), DHEG group (50 mg/kg hydroalcholic extracts of Galega officinalis), DG group (5 mg/kg glibenclamide). After 20 days, rats’ blood samples, kidney, liver, and pancreas were kept in -70 °C to test blood levels of glucose, insulin, lipid profile, some oxidative stress markers and anti-oxidant enzymes. Results: The  levels FBS in Normal, DHEG, and DG groups were significantly lower than DC group (p .05); MDA was significantly increased in DC group (p .05). SOD was significantly low in DC group, but, in other groups (DHEG, and DG), SOD activities had significant differences compared to the DC group (p<.05) Conclusions: These results indicated that Galega officinalis could be beneficial for treatment of diabetes through against oxidative stress and improve tissue sensitivity to insulin.