Sodium bromide by instrumental neutron activation analysis quantifies change in extracellular water space with wound closure in severely burned children

Abstract Background. The ability to measure extracellular water (ECW) in critically ill patients can significantly enhance current methods of assessing fluid homeostasis, body composition, and response to nutritional therapy. We measured corrected bromide space to determine change in ECW with wound closure among acutely burned children. Methods. Fifteen children with burns over 30% of their total body surface area had their ECW determined following hemodynamic stabilization and when wound closure was complete. Plasma samples were obtained at baseline and 4 hours after receiving 25 mg/kg of sodium bromide. Plasma bromide was quantified by instrumental neutron activation analysis. Results. Mean CBS decreased with wound closure (9.1 ± 4.1 vs 7.9 ± 3.9 liters; P =.04), indicating a significant decrease in ECW over the course of recovery. A decline in weight also occurred over the same period (32.4 ± 15.2 vs 29.1 ± 13.5 kg; P =.007); however, change in corrected bromide space as a proportion of weight was not statistically significant. Conclusion. A significant decrease in ECW accompanies the weight loss observed in patients following wound closure. Measurement of bromide dilution space is a convenient method for monitoring ECW that can be done at the bedside. (Surgery 2003;133:396-403.)