IRGM1 Deficiency Selectively Affects Intestinal Paneth Cell Morphology and Function

G A A b st ra ct s features irregular thickening of epithelium and variable width of capillaries, the % of agreement was 41.5% and 44.5%, respectively, while estimates of kappa were 0.12 and 0.11, respectively. Discussion: In this study we attempted to create classification criteria for advanced adenomas of the colon using selected features during a preliminary review of randomized pCLE videos. Overall sensitivity was low, albeit improving when diagnoses were changed to advanced when confidence level was low. Despite this, NPV is high due to the low prevalence of advanced neoplasia. Further refinement in the classification scheme is required before a diagnose and discard strategy can be implemented in routine clinical practice. The moderate inter observer agreement for certain feature does have promising implications. However, further studies are needed to confirm these findings.