LL-D49194 antibiotics, a novel family of antitumor agents. Taxonomy, fermentation and biological properties.
1990
A novel family of antitumor antibiotics, designated LL-D49194, was isolated from the fermentation broth of an actinomycete strain identified as Streptomyces vinaceus-drappus. LL-D49194 α 1 and β 2 were active against Gram-positive and inactive against Gram-negative bacteria in vitro. The β 1 component was not active against either Gram-positive or Gram-negative bacteria. These antibiotics exhibited significant in vivo activities against several murine tumors, albeit with differing potencies
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